Mental disorders due to permanent stress
Immune cells have harmful effect in the brain
Predisposition may be traced back to embryonic stage
Stress activates the immune system
The team focused mainly on a certain type of phagocytes, namely microglia. Under normal circumstances, they repair synapses between nerves cells in the brain and stimulate their growth. Once activated, however, microglia may damage nerve cells and trigger inflammation processes. The studies carried out in Bochum have shown that the more frequently microglia get triggered due to stress, the more they are inclined to remain in the destructive mode – a risk factor for mental diseases such as schizophrenia.
Susceptibility for stress effects varies from individual to individual
Not every individual who is under permanent stress will develop a mental disorder. Prof Juckel’s team suspects the cause to go back to the embryonic stage. US researchers demonstrated as far back as the 1950s that children born of mothers who contracted true viral influenza during pregnancy were seven times as likely to suffer schizophrenia later in life. The researchers from Bochum confirmed this hypothesis in animal models. Now, they a striving to research into the mechanism that makes people susceptible to this disease. “The embryo undergoes some kind of immune response which has far-reaching consequences and presumably shapes the future immune system,” says Dr Astrid Friebe from the LWL clinic.
Detailed article in the science magazine RUBIN
A detailed article with pictures can be found in the online magazine RUBIN, the RUB’s science magazine: http://rubin.rub.de/en/featured-topic-stress/mental-disorders. Text and images on the download page are free for use for editorial purposes, provided the relevant copyright notice is included. You would like to receive a notification when new RUBIN articles are published? Then subscribe to our news feed at http://rubin.rub.de/feed/rubin-en.rss.